Journal: Investigational New Drugs
Article Title: Scorpio fuscus venom as a promising anticancer agent against colorectal cancer
doi: 10.1007/s10637-026-01598-z
Figure Lengend Snippet: Histopathology and immunohistochemistry (IHC) analyses. a Representative H&E-stained section from the control group showing normal intestinal architecture with preserved crypt structures (arrows). b H&E-stained section from the CDX group displaying disrupted tissue architecture, densely packed malignant epithelial cells, and invasive tumor margins (arrow). c Immunohistochemical staining for Bax in tumor tissues from the CDX + SFV group, demonstrating increased pro-apoptotic protein expression (arrows). d Immunohistochemical staining for BcL-2 in tumor tissues from the CDX group, indicating strong anti-apoptotic protein expression (arrows). Scale bars: 100 µm ( a , b ), 10 µm ( c , d )
Article Snippet: Human CRC cell lines (DLD-1, HT-29, Caco-2) and human healthy colon epithelial cell line (CCD-18Co) were purchased from the American Type Culture Collection (ATCC, Rockville, MD).
Techniques: Histopathology, Immunohistochemistry, Staining, Control, Immunohistochemical staining, Expressing